• Reprogramming orthogonal regulatory and metabolic system for scalable production of secondary metabolites.
  Nature Chemical Engineering. 2026-09. (Accept)
• Scalable secondary metabolite production in Streptomyces using a plug-and-play system.
  Nature Biotechnology. 2025-08. DOI: 10.1038/s41587-025-02762-1.
• Orchestration of secondary metabolite production in Streptomyces species.
  Nature Biotechnology. 2025-09. DOI: 10.1038/s41587-025-02762-1.
• High-yield Porphyrin Production through Metabolic Engineering and Biocatalysis.
  Nature Biotechnology. 2024-06. DOI: 10.1038/s41587-024-02267-3.
• Harnessing the Intracellular Triacylglycerols for Titer Improvement of Polyketides in Streptomyces.
  Nature Biotechnology. 2019-12. DOI: 10.1038/s41587-019-0335-4.
• Profile and Relaxation of Sequence-Specificity of DNA Sulfur Binding Domains Facilitate New Nucleic Acid Detection Platform.
  Science Bulletin. 2023-08. DOI: 10.1016/j.scib.2023.07.012.
• Berberine Reverses Multidrug Resistance in Candida Albicans by Hijacking the Drug Efflux Pump Mdr1p.
  Science Bulletin. 2021-09. DOI: 10.1016/j.scib.2020.12.035.
• A Versatile Biosensing Platform Coupling CRISPR–Cas12a and Aptamers for Detection of Diverse Analytes.
  Science Bulletin. 2021-01. DOI: 10.1016/j.scib.2020.09.004.
• Reprogramming ThDP Enzymes for Z-Alkenes: Overriding Thermodynamic Preference via Noncovalent Controls.
  Journal of the American Chemical Society. 2026-06. DOI: 10.1021/jacs.6c06951.
• Enzyme-Catalyzed Intramolecular C–C Coupling Transformation of Nitriles.
  Journal of the American Chemical Society. 2026-02. DOI: 10.1021/jacs.6c02210.
• Taming Highly Enolizable Aldehydes via Enzyme Catalysis for Enantiocomplementary Construction of β-Hydroxyphosphonates.
  Journal of the American Chemical Society. 2025-01. DOI: 10.1021/jacs.4c11957.
• Structural and mechanistic insights into azetidine-associated αKG-NHFe enzyme OkaE with multifunctional catalysis
  Nature Communications. 2026-02. DOI: 10.1038/s41467-026-69519-5.
• A Thermostable Type IB CRISPR-Cas System for Orthogonal and Multiplexed Genetic Engineering.
  Nature Communications. 2023-10. DOI: 10.1038/s41467-023-41973-5.
• A CRISPR-Cas12a-Derived Biosensing Platform for the Highly Sensitive Detection of Diverse Small Molecules.
  Nature Communications. 2019-08. DOI: 10.1038/s41467-019-11648-1.
• Model-Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132.
  Advanced Science. 2025-09. DOI: 10.1002/advs.202511411.
• Harnessing a Previously Unidentified Capability of Bacterial Allosteric Transcription Factors for Sensing Diverse Small Molecules in Vitro.
  Science Advances. 2018-11. DOI: 10.1126/sciadv.aau4602.
• Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS.
  Angewandte Chemie International Edition. 2024-09. DOI: 10.1002/anie.202406246.
• Development of an Escherichia coli-based diterpenoid bioproduction foundry.
  Chemical Engineering Journal. 2026-11. DOI: 10.1016/j.cej.2026.180407.
• Expanding horizons of CRISPR applications beyond genome editing.
  Trends in Genetics. 2025-07. DOI: 10.1016/j.tig.2025.06.003.
• Systematic Development of a Highly Efficient Cell Factory for 5-Aminolevulinic Acid Production.
  Trends in Biotechnology. 2024-11. DOI: 10.1016/j.tibtech.2024.06.004.
• Unleashing the Potential: Type I CRISPR-Cas Systems in Actinomycetes for Genome Editing.
  Natural Product Reports. 2024-06. DOI: 10.1039/D4NP00010B.
• Anti-Mycobacterial Natural Products and Mechanisms of Action.
  Natural Product Reports. 2021-07. DOI: 10.1039/D1NP00011J.
• ETfinder: harnessing conserved C-terminal tails of single-stranded DNA-binding proteins for mining and engineering RecET systems in non-model microbial chassis.
  Nucleic Acids Research. 2026-08. DOI: 10.1093/nar/gkag818.
• Activating Cryptic Biosynthetic Gene Cluster through a CRISPR–Cas12a-Mediated Direct Cloning Approach.
  Nucleic Acids Research. 2022-03. DOI: 10.1093/nar/gkac181.
• Reporter systems in actinomycetes: Versatile tools for natural product discovery and production.
  Biotechnology Advances. 2026-05. DOI: 10.1016/j.biotechadv.2026.108831.
• Engineering the D‑Helix in Fungal Sesterterpene Synthase ZbSS Unlocks a Skeletal Rearrangement Cyclization Route toward Sesterterpene Diversification.
  ACS Catalysis. 2026-02. DOI: 10.1021/acscatal.5c07482.
• G2 Helix as the Plastic Region Modulating Diastereoselectivity of Cyclization in Fungal Bifunctional Sesterterpene Synthases.
  ACS Catalysis. 2025-07. DOI: 10.1021/acscatal.5c03947.
• Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization.
  ACS Catalysis. 2025-01. DOI: 10.1021/acscatal.4c06881.
• Biochemical and Structural Characterization of OvoA_Th2: A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis.
  ACS Catalysis. 2023-11. DOI: 10.1021/acscatal.3c04026.
• Hydrogenase as the Basis for Green Hydrogen Production and Utilization.
  Journal of Energy Chemistry. 2023-10. DOI: 10.1016/j.jechem.2023.06.018.

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